Activation of β-Catenin in Mesenchymal Progenitors Leads to Muscle Mass Loss
Researchers found the canonical Wnt pathway to be activated in mesenchymal progenitors from cancer-induced cachectic mouse muscle, and then induced β-catenin transcriptional activity in murine mesenchymal progenitors.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.