Therapeutic Activation of Endothelial Sphingosine-1-Phosphate Receptor 1 by Chaperone-Bound S1P Suppresses Proliferative Retinal Neovascularization

Researchers showed in a mouse model of oxygen-induced retinopathy that endothelial overexpression of S1pr1 suppressed while endothelial knockout of S1pr1 worsened neovascular tuft formation.
[EMBO Molecular Medicine]
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