Therapeutic Activation of Endothelial Sphingosine-1-Phosphate Receptor 1 by Chaperone-Bound S1P Suppresses Proliferative Retinal Neovascularization
Researchers showed in a mouse model of oxygen-induced retinopathy that endothelial overexpression of S1pr1 suppressed while endothelial knockout of S1pr1 worsened neovascular tuft formation.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.
[EMBO Molecular Medicine] WD-repeat 6 (WDR6) deficiency in hepa1-6 cells drastically inhibited the growth and lung metastasis of orthotopically implanted tumors in immune-competent C57BL/6J mice.