Methylation of Histone H3 Lysine 4 Is Required for Maintenance of Beta Cell Function in Adult Mice
Researchers investigated whether methylation of histone H3 lysine 4, a marker of gene promoters with unresolved functional importance, is necessary for the maintenance of mature beta cell function.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.