The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo
To identify how loss of Chd4 impacts glucose homeostasis and gene expression programs in β-cells in vivo, researchers generated an inducible-β-cell-specific Chd4 knockout mouse model.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.