Accumulation of Branched-Chain Amino Acids Reprograms Glucose Metabolism in CD8⁺ T Cells with Enhanced Effector Function and Anti-Tumor Response

Branched-chain amino acid (BCAA) supplementation recapitulated CD8+ T cell hyper-functions and synergized with anti-PD-1, in line with a better prognosis in non-small cell lung cancer patients containing high BCAAs when receiving anti-PD-1 therapy.