Linoleic Acid Potentiates CD8+ T Cell Metabolic Fitness and Antitumor Immunity
The authors showed that linoleic acid was a major positive regulator of CD8+ T cell activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phenotype with superior effector functions.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.