MAdCAM-1 Costimulation in the Presence of Retinoic Acid and TGF-β Promotes HIV Infection and Differentiation of CD4+ T Cells Into CCR5+ TRM -Like Cells
Among the costimulatory ligands the authors evaluated, MAdCAM-1 was unique in its capacity to upregulate both CCR5 and CCR9. MAdCAM-1 costimulation rendered cells susceptible to HIV infection.
[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.