SARS-CoV-2 Spike Protein-Mediated Cardiomyocyte Fusion May Contribute to Increased Arrhythmic Risk in COVID-19
To assess the cellular and electrophysiological effects of direct SARS-CoV-2 infection of the heart, researchers studied human induced pluripotent stem cell-derived cardiomyocytes.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.