The Immunometabolite Itaconate Stimulates OXGR1 to Promote Mucociliary Clearance during the Pulmonary Innate Immune Response

Investigators identified itaconate as an orthosteric agonist of the GPCR OXGR1, with an EC50 of approximately 0.3 mM, which was in the same range as the physiological concentration of extracellular itaconate upon macrophage activation.