Placental Cell Type Deconvolution Reveals That Cell Proportions Drive Preeclampsia Gene Expression Differences
Scientists generated single-cell RNA-sequencing samples for integration with existing data to create the largest deconvolution reference of 19 fetal and eight maternal cell types from placental villous tissue.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.