The SMARCA4R1157WM Mutation Facilitates Chromatin Remodeling and Confers PRMT1/SMARCA4 Inhibitors Sensitivity in Colorectal Cancer

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Researchers showed that the SMARCA4R1157WM mutant reinforced the transcriptional expression of EGFR and TNS4 to promote the proliferation of colorectal cancer cells and patient-derived tumor organoids.
[NPJ Precision Oncology]
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