The SMARCA4^R1157WM Mutation Facilitates Chromatin Remodeling and Confers PRMT1/SMARCA4 Inhibitors Sensitivity in Colorectal Cancer

Researchers showed that the SMARCA4R1157WM mutant reinforced the transcriptional expression of EGFR and TNS4 to promote the proliferation of colorectal cancer cells and patient-derived tumor organoids.