Loss of LGR5 through Therapy-Induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

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Combination treatment of MET-STAT3 inhibitors with irinotecan or antibody-drug conjugates substantiated synergistic effects in colorectal cancer cells and tumor organoids.
[Molecular Cancer Therapeutics]
Abstract