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e.g. organoids

Age-Associated Microenvironmental Changes Highlight the Role of PDGF-C in ER+ Breast Cancer Metastatic Relapse

Investigators used syngeneic ER+ mouse models in which disseminated tumor cells displayed a dormant phenotype in young mice but accelerated metastatic outgrowth in an aged or fibrotic microenvironment.
[Nature Cancer]
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