Tumor-Expressed Factor VII Associates with Survival and Regulates Tumor Progression in Breast Cancer
In breast cancer cell lines, tumor-expressed FVII drove changes reminiscent of epithelial-to-mesenchymal transition, tumor cell invasion, and expression of the pro-metastatic genes SNAI2 and SOX9.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.