Intercellular HIF1a Reprogams Mammary Progenitors and Myeloid Immune Evasion to Drive High-Risk Breast Lesions

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The authors showed that invasive breast cancer cells exposed to hypoxia released small extracellular vesicles that disrupted the differentiation of normal mammary epithelia, expanded stem and luminal progenitor cells, and induced atypical ductal hyperplasia and intraepithelial neoplasia.
[Journal Of Clinical Investigation]
AbstractGraphical Abstract