CAR Links Hypoxia Signaling to Improved Survival after Myocardial Infarction

To elucidate whether the coxsackievirus and adenovirus receptor (CAR) contributed to hypoxia signaling and myocardial infarction pathology, researchers used a gain- and loss-of-function approach in transfected HEK293 cells, H9c2 cardiomyocytes and CAR knockout mice.