Stepwise Activities of mSWI/SNF Family Chromatin Remodeling Complexes Direct T Cell Activation and Exhaustion

Researchers comprehensively profiled the genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute and chronic T cell stimulation, finding that stepwise changes in localization over transcription factor binding sites directed site-specific chromatin accessibility and gene activation leading to distinct phenotypes.