SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake

In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastomas cholesterol biosynthesis, proliferation, and self-renewal.