The Transmembrane Protein TM4SF3 Interacts with AR and AR-V7 and is Recruited to AR Target Genes

Scientists mapped the interaction domains within the androgen receptor (AR) and transmembrane 4 superfamily 3 (TM4SF3) and discovered that TM4SF3 also physically interacted with AR-V7, regulating its protein stability and the viability of castration-resistant prostate cancer cells expressing AR-V7.