Endothelial K_Ca3.1 and K_Ca2.3 Mediate S1P (Sphingosine-1-Phosphate)–Dependent Vasodilation and Blood Pressure Homeostasis

Isolated mouse mesenteric artery and endothelial cell models were used to determine S1P-induced vasodilation, intracellular calcium, membrane potentials, and calcium-activated potassium channels, KCa3.1 and KCa2.3.