Preferential Hematopoietic Differentiation in Induced Pluripotent Stem Cells Derived from Human Umbilical Cord Arterial Endothelial Cells

Human induced pluripotent stem cells (hiPSCs) were generated from somatic cells by transduction of 4 human transcription factors using Sendai virus vectors. Genome-wide DNA methylation analysis and transcriptional analysis were performed to evaluate the pluripotent capacity and somatic memory state of hiPSCs.