Endothelial Cell Vasodilator Dysfunction Mediates Progressive Pregnancy-Induced Hypertension in Endothelial Cell Tetrahydrobiopterin Deficient Mice

The vascular reactivity of mouse aortas and uterine arteries from non-pregnant and pregnant endothelial cell-specific tetrahydrobiopterin deficient mice was assessed by wire myography. Systolic blood pressure was assessed by tail cuff plethysmography.