Imatinib Blocks Tyrosine Phosphorylation of Smad4 and Restores TGF-β Growth-Suppressive Signaling in BCR-ABL1-Positive Leukemia

Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Signal Transduction and Targeted Therapy]
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