Latexin Regulates Sex Dimorphism in Hematopoiesis via Gender-Specific Differential Expression of microRNA 98–3p and Thrombospondin 1

Scientists found no differences in HSC function and hematopoiesis in latexin (Lxn) knockout male mice under physiologic and myelosuppressive conditions. They also found that thrombospondin 1, a downstream target gene of Lxn in female HSCs, was repressed in male HSCs.