A Self-Propagating C-Met-SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

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The sialylated cancer IgG(SIA-cIgG)/c-Met/SOX2/SIA-cIgG signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo.
[Cancer Research]
Abstract