TRAF4-Mediated Nonproteolytic Ubiquitination of Androgen Receptor Promotes Castration-Resistant Prostate Cancer

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Scientists demonstrated that atypical ubiquitination of androgen receptor mediated by an E3 ubiquitin ligase TRAF4 played an important role in castration-resistant prostate cancer development.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract