Genetic or Therapeutic Neutralization of ALK1 Reduces LDL Transcytosis and Atherosclerosis in Mice

Investigators showed that genetic deletion of activin-like kinase receptor (ALK1) in arterial endothelial cells of mice substantially limited low-density lipoprotein accumulation, macrophage infiltration and atherosclerosis without affecting cholesterol or triglyceride levels.
[Nature Cardiovascular Research]
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