Endothelial Cell-Released Extracellular Vesicles Trigger Pyroptosis and Vascular Inflammation to Induce Atherosclerosis through the Delivery of HIF1A-AS2

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Researchers assayed the clinical significance of endothelial cell (EC)-derived extracellular vesicles (EVs) in atherosclerosis (AS). Expression of HIF1A-AS2, miR-455-5p, and ESRRG in plasma from AS patients and mice and EVs from ox-LDL-treated ECs was measured.
[FASEB Journal]
Abstract