Identification of Anoikis-Related Subtypes and Development of Risk Stratification System in Skin Cutaneous Melanoma
The data from TCGA corresponding to transcriptomic expression patterns for patients with skin cutaneous melanoma were downloaded and utilized to screen distinct molecular subtypes by a non-negative matrix factorization algorithm.
[EMBO Journal] Using a variety of in vitro and in vivo techniques, researchers showed that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion.
[Molecular Cell] Investigators explored the role of minor intron-containing genes and minor spliceosome in cancer, taking prostate cancer as an exemplar.
[Nature Communications] The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.