Skeletal Muscle Delimited Myopathy and Verapamil Toxicity in SUR2 Mutant Mouse Models of AIMS

Given the roles of the SUR2 subunit of ATP-sensitive potassium KATPM channels in all muscles, investigators sought to determine how myopathy arises using tissue-selective suppression of KATP, and found that loss-of-function in skeletal muscle, specifically, underlies myopathy.
[EMBO Molecular Medicine]
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