Synthesis and Cytotoxicity Assessment against Human Colorectal Cancer Cell Lines of Quaternary 8-Dichloromethyl Protoberberine Alkaloids

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Twenty-two quaternary 8-dichloromethylprotoberberine alkaloids were synthesized from premodified quaternary protoberberine alkaloids (QPAs) as substrates to improve physical and chemical properties and to obtain selectively anticancer QPA derivatives.
[Chemistry & Biodiversity]
Abstract