MutSα and MutSβ as Size-Dependent Cellular Determinants for Prime Editing in Human Embryonic Stem Cells
Through homozygous knockout of MMR pathway key proteins MSH2, MSH3, and MSH6, scientists revealed that MutSα and MutSβ determined prime editor efficiency in an editing size-dependent manner.
[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.
[Science Immunology] Scientists identified OTULIN deficiency as a cellular condition that licenses RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.
[Cellular & Molecular Immunology] Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome.