Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression

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Scientists reported that cancer cells could upregulate surface macrophage receptor with collagenous structure (MARCO) expression on human macrophages not only via IL-6–induced STAT3 activation but also via sphingosine-1-phosphate receptor-mediated IL-6 and IL-10 expression followed by STAT3 activation.
[Journal of Immunology]
Abstract