MSC-NPRA Loop Drives Fatty Acid Oxidation to Promote Stemness and Chemoresistance of Gastric Cancer
The chemoresistance and stemness of gastric cancer cells were observed by colony formation, CCK-8, sphere formation, and flow cytometry assays. Cell lines and animal models were utilized to investigate related functions.
[Haematologica] 301 patients with a median age 60 years were enrolled. Of them, 287 and 274 patients collected ≥2 and ≥4×106 CD34+ cells/kg, respectively, with a median of 9.9×106 CD34+ cells/kg collected.
[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.