Subscribe
e.g. organoids

USP7 Represses Lineage Differentiation Genes in Mouse Embryonic Stem Cells by Both Catalytic and Noncatalytic Activities

Researchers reported that USP7 maintains mESC identity through both catalytic activity–dependent and –independent repression of lineage differentiation genes. Usp7 depletion attenuated SOX2 levels and derepresses lineage differentiation genes thereby compromising mESC pluripotency.
[Science Advances]
Full Article
Published In
NewslettersESC & iPSC News
spot_img

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News

Anti-Warburg Effect via Generation of ROS and Inhibition of PKM2/β-Catenin Mediates Apoptosis of Lambertianic Acid in Prostate Cancer Cells

[Phytotherapy Research] To elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells.
NewslettersProstate Cell News
Read more

Integrated High-Throughput Analysis Identifies Super Enhancers in Metastatic Castration-Resistant Prostate Cancer

[Frontiers In Pharmacology] Super enhancer-associated genes and transcription factors were identified from a cell line of metastatic castration-resistant prostate cancer (mCRPC) by the CUT&Tag assay. Differentially expressed genes between mCRPC and primary prostate cancer samples in the GSE35988 dataset were identified.
NewslettersProstate Cell News
Read more

Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture Microenvironment

[Frontiers In Oncology] To facilitate the practical application of human embryonic stem cells (hESCs), scientists established a co-culture system consisting of prostate cancer cell lines and hESCs and investigated the antitumor activity of the supernatant of the co-culture system in vitro and in vivo.
ESC & iPSC NewsNewslettersProstate Cell News
Read more
Brought to you by