RTK Signaling Promotes Epithelial Columnar Cell Shape and Apical Junction Maintenance in Human Lung Progenitor Cells
Cell shape dynamics and fate are tightly coordinated during development, therefore researchers used an organoid system to identify signaling pathways that maintained the columnar shape of human lung tip progenitors.
[Scientific Reports] Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.
[Cell Death & Disease] Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.
[Nature Structural & Molecular Biology] Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.