Tenascin-C Activation of Lung Fibroblasts in a 3D Synthetic Lung Extracellular Matrix Mimic

Researchers developed a synthetic, bioactive hydrogel that mimics the native lung modulus and includes a representative distribution of the most abundant extracellular matrix peptide motifs responsible for integrin binding and matrix metalloproteinase-mediated degradation in the lung, which enabled quiescent culture of human lung fibroblasts.