Aberrant Expression of Bone Morphogenetic Proteins in the Disease Progression and Metastasis of Breast Cancer
Expression of bone morphogenetic protein (BMP), BMP receptors, and antagonists in breast cancer were analyzed by using TCGA-BRCA and E-MTAB-6703 cohorts.
[Haematologica] 301 patients with a median age 60 years were enrolled. Of them, 287 and 274 patients collected ≥2 and ≥4×106 CD34+ cells/kg, respectively, with a median of 9.9×106 CD34+ cells/kg collected.
[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.