Curcumin Activates a ROS/KEAP1/NRF2/miR-34a/b/c Cascade to Suppress Colorectal Cancer Metastasis

Scientists used a genetic approach to determine the role of the p53/miR-34 pathway as mediator of the effects of curcumin. Three isogenic colorectal cancer cell lines rendered deficient for the p53, miR-34a, and/or miR-34b/c genes were exposed to curcumin and subjected to cell biological analyses.