Tumor-Intrinsic Sensitivity to the Pro-Apoptotic Effects of IFN-γ Is a Major Determinant of CD4+ CAR T-Cell Antitumor Activity

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With the help of functional intravital imaging, scientists reported that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19 CD4+ CAR T cells.
[Nature Cancer]
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