Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

A single adeno-associated virus-humanTMPRSS3 injection in Tmprss3A306T/A306T mice of an average age of 18.5 months led to the sustained rescue of the auditory function to a level similar to wild-type mice.