The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Scientists identified a function of cyclin F to regulate substrate solubility and showed how cyclin F mechanistically underlay amyotrophic lateral sclerosis and frontotemporal dementia disease pathogenesis.