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e.g. organoids

PROX1 Induction by Autolysosomal Activity Stabilizes Persister-Like State of Colon Cancer via Feedback Repression of the NOX1-mTORC1 Pathway

Researchers showed that enhanced autolysosomal activity mediated by mTORC1 inhibition induced PROX1 expression and that PROX1 induction in turn inhibited NOX1-mTORC1 activation.
[Cell Reports]
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