POLQ Inhibition Elicits an Immune Response in Homologous Recombination–Deficient Pancreatic Adenocarcinoma via cGAS/STING Signaling

Using human and murine homologous recombination (HR)-deficient PDAC models, scientists found that polymerase theta knockdown was synthetically lethal in combination with mutations in HR genes such as BRCA1 and BRCA2 and the DNA damage repair gene