Targeting Pancreatic Cancer With Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation

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Investigators synthesized a series of plumbagin derivatives and found that 2-(cyclohexylmethyl)-plumbagin inhibited the PI3K/Akt/mTOR signaling pathways, leading to cancer cell death under nutrient-deprived conditions.
[Journal Of Medicinal Chemistry]
AbstractGraphical Abstract