Saikosaponin B2 Ameliorates Depression-Induced Microglia Activation by Inhibiting Ferroptosis-Mediated Neuroinflammation and ER Stress

Investigators evaluated the anti-inflammatory effect and elucidated underlying molecular mechanisms of saikosaponins B2 in lipopolysaccharide-induced primary microglia and chronic unpredictable mild stress-induced mice model of depression.