Histone H2A Lys130 Acetylation Epigenetically Regulates Androgen Production in Prostate Cancer

The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.