Investigation of Enzalutamide, Docetaxel, and Cabazitaxel Resistance in the Castration Resistant Prostate Cancer Cell Line C4 Using Genome-Wide CRISPR/Cas9 Screening
To identify genes that modulated treatment response to these drugs, the authors performed three genome-wide CRISPR/Cas9 knockout screens in the metastatic CRPC cell line C4.
[Cell & Bioscience] Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.