A Mitochondrial EglN1-AMPKα Axis Drives Breast Cancer Progression by Enhancing Metabolic Adaptation to Hypoxic Stress

Researchers found that the prolyl hydroxylase EglN1 accumulated on mitochondria under hypoxia. EglN1 substrate-binding region in the β2β3 loop was responsible for its mitochondrial translocation and contributed to breast tumor growth.
[EMBO Journal]
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