Genetically Engineered Mesenchymal Stem Cells as a Nitric Oxide Reservoir for Acute Kidney Injury Therapy
Human MSCs were genetically modified to produce mutant β-galactosidase. Furthermore, a new nitric oxide prodrug, 6-methyl-galactose-benzyl-oxy NONOate, was designed.
[Cell & Bioscience] Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.